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James Shapiro obtained his medical degree from the University of Newcastle upon Tyne and trained in surgery at the University of Bristol. After coming to Canada in 1993, he received training in liver transplantation and hepatobiliary surgery at the University of Alberta and earned a Ph.D. in Experimental Surgery.
Shapiro developed a brand new approach to optimize islet cell transplant engraftment that involved a radical departure from previous practice. Of almost 300 islet transplants attempted before 1999, fewer than 10% of these worked in patients. His protocol was designed to address many of the previous shortcomings by transplanting sufficient numbers of islets into the liver by using multiple donors, and by testing a novel anti-rejection strategy that avoided steroids and allowed the transplanted islets to work at their best. The result became known internationally as the ‘Edmonton Protocol.’
Shapiro led the clinical team that tested his approach in seven initial patients, all of whom (100%) were able to discontinue the need for insulin injections for periods beyond a year. He was the lead author in the landmark paper published in July 2000 that described these results. Since then, he and his team have transplanted almost 300 Canadians and have continued to refine and optimize the protocol. This treatment has been replicated many times internationally, and over 2000 patients worldwide have now received islet transplants using the backbone of his protocol.
A large ‘registration’ trial conducted in Canada and the USA reported its positive findings in 2016 in the Journal Diabetes Care. Countries including England, Scotland, France, Switzerland, Australia, and Canada have approved and funded islet transplantation as part of the ‘standard of care for patients with brittle, difficult-to-control, forms of Type 1 diabetes.
Since the development of the Edmonton Protocol, he has led or co-led three major ongoing international multicentre clinical trials to further improve islet transplantation outcomes. He leads the Edmonton team, which is the largest islet transplantation team worldwide. Shapiro also led the first-in-human stem cell transplant trials in Edmonton, Canada in 2014, and continues to refine stem cell transplantation approaches in patients. So far these studies are proving both promising and safe when tested in Canadians.
In his basic science laboratory, Professor Shapiro developed a new means to transplant cells beneath the skin by using a temporary tube to induce new blood vessels to grow. Before then, islet transplants beneath the skin failed universally, but this treatment is now known as the ‘Deviceless Technique’.
In liver transplantation research, Shapiro and his team recently conducted two trials in Edmonton of a new machine designed to incubate and keep donated human livers alive outside the body before transplantation. This technology is radically altering our ability to rescue damaged livers and provide safer livers for transplant. It is also allowing these transplants to happen during regular daylight hours. Professor Shapiro further led a cross-Canadian research team to test similar technologies in heart, lung, kidney and pancreas transplantations as part of the Canadian National Transplant Research Project.
His busy research lab is currently working on more than 30 projects and 15 human clinical trials. One is an exciting immune reset trial. In this study, people newly diagnosed with type 1 diabetes are given a combination of targeted medications designed to reset their immune system and repair the pancreas. Besides maintaining an active immunology/transplant research laboratory, Dr. Shapiro has a busy clinical practice specializing in hepatobiliary and pancreatic surgery, surgical oncology, as well as transplant surgery, and was featured in an internationally acclaimed movie about organ transplantation called ‘Memento Mori.’ A shorter-length version of this called ‘Vital Bonds’ was aired last year across Canada by the CBC’s David Suzuki’s 'The Nature of Things. An edited version called ‘Transplanting Hope’ has been aired across the USA as part of PBS. This movie is helping to raise awareness about organ donation.
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