For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.
Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.
This isn’t just self-improvement - it’s human enhancement backed by data.
Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.
Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?
Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.
From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.
What You’ll Learn:
• The Seven Tenets of Aging and how they’ll change your approach to health
• Why indulging in “bad” habits doesn’t have to sabotage your longevity
• Biochemical secrets to combat oxidative stress, glycation, and cellular junk
• The real story behind NAD, circadian rhythms, and the tools for better sleep
• How to create a personalized health plan that’s sustainable, effective—and fun
Resources:
• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Kaufmann Protocol Website: https://kaufmannprotocol.com
• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047
• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
SPONSORS:
Leela Quantum | Head to https://leelaq.com/DAVE for 10% off.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Timestamps:
• 00:00 Trailer
• 00:45 Guest Introduction
• 02:30 Longevity Insights
• 04:22 Personal Stories
• 08:00 Pharmaceuticals
• 12:26 Diet and Lifestyle
• 18:19 Seven Tenets
• 22:04 Sleep and Circadian Rhythms
• 26:41 NAD and Supplements
• 37:46 Blood Sugar and AGEs
• 47:09 Microcirculation
• 49:08 NRS and Imports
• 49:18 Celebrex Medication
• 50:03 Celebrex Benefits
• 50:41 Alzheimer’s and Celebrex
• 51:28 Antioxidants
• 54:26 Stem Cells and Exosomes
• 58:03 Laser Skin Treatments
• 01:07:34 Hormones and Longevity
• 01:20:03 Lithium for Mood
• 01:27:45 Gender and Longevity
• 01:32:39 Final Thoughts
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