For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.
Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.
This isn’t just self-improvement - it’s human enhancement backed by data.
Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.
Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Today, we’re unlocking the full potential of your brain—starting with Bryan Johnson’s Blueprint for longevity and brain optimization.
We’re revisiting our conversation with Bryan, the creator of the Don’t Die movement (among many other things), to explore how his groundbreaking approach to brain health and biohacking is reshaping the future of longevity.
First, we dive into Bryan’s mission to make brain monitoring as easy as tracking blood glucose, using his Blueprint protocol to measure and optimize cognitive performance for better health and wellness.
Then, we tackle the deeper side of biohacking—longevity, societal reactions to living longer, and how to handle critics when you’re pushing the limits of human potential.
Finally, Bryan shares his personal journey—investing $80M into brain science, building the Blueprint for optimal living, and discovering the power of community and lifelong friendships for a long, vibrant life. This episode will change the way you think about brain health and the future of humanity.
Sponsors:
Resources:
Timestamps and Highlights:
00:00 Introduction and Bold Claims
00:39 Meet Bryan Johnson: The Neuroscience Pioneer
01:23 Kernel: Revolutionizing Brain Measurement
05:51 Biohacking and Longevity
07:30 Facing Criticism and Staying Resilient
16:06 Media Training Insights
19:49 Personal Reflections and Relationships
34:37 Exercise and Longevity
44:46 Optimizing Brain-Body Interface
45:25 Longevity Hacks and Driving Preferences
45:48 Debating Olive Oil and Saturated Fats
46:52 The Blueprint Approach to Health
48:38 Testing and Metrics in Health
52:22 Testosterone and Hormone Protocols
56:27 Exploring Semen Retention
01:00:44 Body Hair and Aesthetics
01:04:26 Psychedelics and Consciousness
01:08:32 Audience Q&A and Final Thoughts
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